If phosphatidylserine is the death knell, a new phosphatidylserine-specific receptor is the bellringer
نویسندگان
چکیده
منابع مشابه
Phosphatidylserine receptors: what is the new RAGE?
the recognition of apoptotic cells by phagocytes is a complex, yet highly orchestrated event. Many receptors have been identified that recognize phosphatidylserine (pS; Fig 1)—which is exposed on early apoptotic cells—leading to downstream signalling and apoptotic cell engulfment. in this issue of EMBo reports, the receptor for advanced glycation endproducts (ragE) is described as a new pS rece...
متن کاملTethering and tickling: a new role for the phosphatidylserine receptor
Contribution of phosphatidylserine receptor to apoptotic cell uptake Apoptosis or programmed cell death occurs during embryogenesis, normal cell turnover, and as a consequence of immune mediated, infectious, or inflammatory effects. Clearance of intact apoptotic cells (ACs)* by phagocytes protects surrounding tissues from intracellular factors and reduces the likelihood of tissue damage caused ...
متن کاملPhosphatidylserine receptor is required for clearance of apoptotic cells.
Cells undergoing apoptosis during development are removed by phagocytes, but the underlying mechanisms of this process are not fully understood. Phagocytes lacking the phosphatidylserine receptor (PSR) were defective in removing apoptotic cells. Consequently, in PSR-deficient mice, dead cells accumulated in the lung and brain, causing abnormal development and leading to neonatal lethality. A fr...
متن کاملMicrovascular endothelial cells express a phosphatidylserine receptor: a functionally active receptor for phosphatidylserine-positive erythrocytes.
Phosphatidylserine (PS)-positive erythrocytes adhere to endothelium and subendothelial matrix components. While thrombospondin mediates these inter-actions, it is unknown whether PS-associated erythrocyte-endothelial adhesion occurs in the absence of plasma ligands. Using ionophore-treated PS-expressing control HbAA erythrocytes, we demonstrate that PS-positive erythrocytes adhered to human lun...
متن کاملPhosphatidylserine is a critical modulator for Akt activation
Akt activation relies on the binding of Akt to phosphatidylinositol-3,4,5-trisphosphate (PIP(3)) in the membrane. Here, we demonstrate that Akt activation requires not only PIP(3) but also membrane phosphatidylserine (PS). The extent of insulin-like growth factor-induced Akt activation and downstream signaling as well as cell survival under serum starvation conditions positively correlates with...
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ژورنال
عنوان ژورنال: Cell Death & Differentiation
سال: 2001
ISSN: 1350-9047,1476-5403
DOI: 10.1038/sj.cdd.4400856